Antibody-points Bulletin: RAB7A
Antibody-points Bulletin: RAB7A
BOLO:
Name: Ras-related Protein Rab-7a 1
PID: P51149
GID: 7879
Nicknames: RAB7A
AKA: RAB7
Vitals:
Origins: 3q21.3
DNA: 88663 bp, NC_000003 (128726136..128814798)
RNA: 2240 bp
Exons: 6
Protein: 207 aa, 23.5 kDa
Description:
Be on the lookout for RAB7A: RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.
Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity).
Last Known Addresses:
• Phagosome Membrane
• Late Endosome Membrane
• Lysosome Membrane
• Melanosome Membrane
Known Hangouts:
Source: NCBI
Gang Associations:
• Antigen Processing And Presentation Of Exogenous Peptide Antigen Via Mhc Class Ii Source
• Autophagosome Assembly
• Bone Resorption
• Early Endosome To Late Endosome Transport
• Early Endosome To Late Endosome Transport
• Endocytosis
• Endosome To Lysosome Transport
• Epidermal Growth Factor Catabolic Process
• Lipophagy Source:
• Membrane Organization
• Multi-Organism Intracellular Transport
• Negative Regulation Of Exosomal Secretion
• Negative Regulation Of Intralumenal Vesicle Formation
• Neutrophil Degranulation
• Phagosome Acidification
• Phagosome-Lysosome Fusion
• Phagosome Maturation
• Positive Regulation Of Exosomal Secretion
• Positive Regulation Of Protein Catabolic Process
• Positive Regulation Of Viral Process
• Protein Targeting To Lysosome
• Protein To Membrane Docking
• Protein Transport Source
• Retrograde Transport, Endosome To Golgi
• Viral Release From Host Cell
Known Weaknesses: None
Means of Capture:
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